On my Reprap-like 3D printer, I routed all the wires to a spot near the base; for the motors, endstops, thermistors, etc, I plugged them all into a DB25 breakout board, and that's working great.
For my Extruder (12v), and my heat bed (16v), I'm using a 4-pin molex connector -- like we used to use for old hard drives and such, and it's working, but it gets a bit hot, and my print bed is having trouble reaching temperatures that it didn't have trouble with before. -- None of the wiring gets hot at any other point, and none of the other connectors get hot. -- The only thing that gets hot is this one molex connector.
I believe the heat is caused by passing too much current through that molex connector. -- I'm curious to know what other connectors might be better suited to this task. Can you recommend something that's worked well for you, or others?
I prefer not to double or triple up this connector if it can be avoided, so that I can just have one physical connector to disconnect there, and so that I don't end up mixing them up. -- also, being able to easily disconnect it is important (it's hard to work on the reprap if I can't spin it around or turn it over, etc., that's why I'm using connectors for everything).