The drawback of RAMPS 1.5 and 1.6 are that they use SMD polyfuses which are a little more difficult to replace (for some people) than the large fuses from the RAMPS 1.4. However, the fuses of the RAMPS 1.4 are sticking out, then tend to bend once in a while when you work on the board and could therefore become prone to metal fatigue and break.
Adding on top of this answer about cable wiring:
For these type of connectors:
please use ferrules on the cable ends for wires that transport high loads/currents and use screw terminals:
For these type of connectors:
please use y-type or fork connectors: